 Ronald L. McNeel, Dr.P.H.
Instructor
Baylor College of Medicine
rmcneel@bcm.tmc.edu
Effects of Macronutrients and Dietary
Supplements on Adipocyte Gene Expression and Lipid
Homeostasis
Research interests include evaluation of the role
of dietary supplements and macronutrients in disease
prevention and in reduction of risk factors associated
with disease. Specific interests include the effects
of macronutrients and dietary supplements (including
herbals) on whole body lipid metabolism and energy
homeostasis with emphasis on lipid metabolism of the
adipocyte. The goal is to obtain a more complete understanding
of the molecular mechanisms of action of macronutrients
and dietary supplements as they relate to fat mass
accretion. Special emphasis is given to the role of
the peroxisome proliferator-activated receptor family,
including PPAR alpha, PPAR beta, and PPAR gamma as
well as their target genes in response to nutrient
signaling. This understanding is critical for the development
of new health promotion strategies and therapeutic
approaches (nutritional, alternative herbal, and pharmacological)
to the management and prevention of nutritional obesity.
Representative Publications:
McNeel, R.L., and H.J. Mersmann, (2005).
Low- and high-carbohydrate diets: Variations in rat
energy expenditure and body composition. Obesity Research
(In Press).
McNeel, R.L., and H.J. Mersmann, (2003). Isomers
of conjugated linoleic acid modulate human preadipocyte
differentiation. In Vitro Cellular & Developmental
Biology 39: 375-382.
McNeel, R.L., and H.J. Mersmann, (2003). Effects
of isomers of conjugated linoleic acid on porcine adipocyte
growth and differentiation. Journal of Nutritional
Biochemistry 14: 266-274.
Ding, S.T., R.L. McNeel, H.J. Mersmann, (2002) Modulation
of adipocyte determination and differentiation-dependent
factor 1 by selected polyunsaturated fatty acids, In
Vitro Cellular & Developmental Biology 38:352-357.
McNeel, R.L. and H.J. Mersmann, (2000) Nutritional
deprivation reduces the transcripts for transcription
factors and adipocyte-characteristic proteins in porcine
adipocytes, J. Nutritional Biochemistry 11:139-146.
McNeel, R.L., S.T. Ding, E. O'Brian Smith, H.J.
Mersmann, (2000) Effect of feed restriction on adipose
tissue transcript concentrations in genetically lean
and obese pigs, J Animal Science 78:934-942.
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