 Dennis
M. Bier, M.D.
Professor of Pediatrics
Baylor College of Medicine
Director, CNRC
dbier@bcm.tmc.edu
Attending Physician
Section of GI and Nutrition
Texas Children's Hospital
Regulation of Interorgan
Transport of Metabolic Fuels
My primary research interest is the regulation of
interorgan transport of metabolic fuels. Specifically,
this interest encompasses the substrate and hormone
regulation of glucose, lipid and protein/amino acid
fuels. Under this rubric, my work has extended
in two principal directions. The first entails
the regulation of endogenous fuel availability for
metabolic functions when a subject is ill and incapable
of ingesting adequate quantities of food. The
second involves the assessment of the metabolic fates
of ingested, exogenous fuels under various classical
nutritional circumstances.
To accomplish these aims, my associates and I have
developed and employed a wide variety of stable-isotope
tracer kinetic methods to quantify substrate flux,
metabolism, precursor-product relationships, and irreversible
oxidation of excreted end products. The physiological
information thus obtained has also been used to further
assess aberrations in interorgan fuel transport consequent
to a wide variety of pathological conditions. In
the upcoming years, I will continue to employ stable
isotope kinetic modeling approaches to address important
developmental and clinical questions concerning the
regulation of fuel transport in infants and children.
Representative publications:
Sunehag AL, Toffolo G, Campioni M, Bier DM, Haymond MW. Effects of dietary macronutrient intake on insulin sensitivity and secretion and glucose and lipid metabolism in healthy, obese adolescents. J Clin Endocrinol Metab. 90(8):4496-4502, 2005.
Zeisel SH, Freake HC, Bauman DE, Bier DM, Burrin DG, German JB, Klein S, Marquis GS, Milner JA, Pelto GH, Rasmussen KM. The nutritional phenotype in the age of metabolomics. J Nutr. 135(7):1613-1616., 2005.
Ciliberto H, Ciliberto M, Briend A, Ashorn P, Bier D, Manary M. Antioxidant supplementation for the prevention of kwashiorkor in Malawian children: randomised, double blind, placebo controlled trial. BMJ. 330(7500):1109, 2005.
Mullis RM, Blair SN, Aronne LJ, Bier DM, Denke MA, Dietz W, Donato KA, Drewnowski A, French SA, Howard BV, Robinson TN, Swinburn B, Wechsler H; American Heart Association.
Prevention Conference VII: Obesity, a worldwide epidemic related to heart disease and stroke: Group IV: prevention/treatment. Circulation. 2;110(18):e484-e488, 2004.
Hanson M, Gluckman P, Bier D, Challis J, Fleming T, Forrester T, Godfrey K, Nestel P, Yajnik C. Report on the 2nd World Congress on Fetal Origins of Adult Disease, Brighton, U.K., June 7-10, 2003. Pediatr Res. 55(5):894-897, 2004.
Bier DM. Amino acid pharmacokinetics and safety
assessment. J Nutr. Jun;133(6 Suppl 1):2034S-2039S,
2003.
Treuth MS, Sunehag AL, Trautwein LM, Bier DM, Haymond
MW, Butte NF. Metabolic adaptation to high-fat and
high-carbohydrate diets in children and adolescents.
Am J Clin Nutr 77:479-89, 2003.
Bier DM. Current uses and future perspectives of
recombinant modifications in food production. In: Genetic
Expression and Nutrition. Nestle Nutrition Workshop
Series Pediatric Program, Volume 50. Lippincott
Williams & Wilkins, Philadelphia, pp 201-218, 2002.
Sunehag AL, Toffolo G, Treuth MS, Butte NF, Cobelli
C, Bier DM, Haymond MW. Effects of dietary macronutrient
content on glucose metabolism in children. J Clin
Endocrinol. & Metab. 87 (11):5168-5178, 2002.
Miller TL, Easely KA, Zhang W, Orav EJ, Bier DM,
Luder E, Ting A, Shearer WT, Vargas JH, Lipshultz
SE. Maternal and infant factors associated with failure
to thrive in children with vertically transmitted HIV-1
infection: The prospective P2C2 HIV multicenter study. Pediatr. 108:1287-1296,
2001.
Kalhan S, Bier DM, Yaffe S, Catz C, Grave G. Amino
acid metabolism and nutrition in very low birth weight
infants. J Perinatol . 21:320-323, 2001.
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